Human ATP Binding Cassette Transporter C11 (ABCC11) ELISA Kit

The Human ATP Binding Cassette Transporter C11 (ABCC11) ELISA Kit from Assay Genie enables quantitative measurement of the ABCC11 protein, also known as MRP8 (Multidrug Resistance Protein 8), a member of the ATP-binding cassette transporter family implicated in multidrug resistance and apocrine secretion.

ABCC11 is encoded on human chromosome 16q12.1 and harbors a well-characterized single nucleotide polymorphism (rs17822931, Gly180Arg) that determines the wet versus dry earwax phenotype and is correlated with axillary osmidrosis and breast cancer susceptibility. The protein is expressed in apocrine glands, liver, and certain cancer cell lines, and contributes to cellular efflux of cyclic nucleotides, glutathione conjugates, and steroid sulfates.

This microplate-based ELISA is configured for in vitro research applications including cancer drug resistance studies, dermatological research into apocrine gland function, and population genetics investigations of the ABCC11 polymorphism. The assay uses a human-specific capture antibody with no significant cross-reactivity reported against rat or mouse orthologues, supporting specific detection across tissue homogenates and cell lysates.