Human Angiotensin-converting enzyme 2 (ACE2) ELISA Kit

From Assay Genie, this Sandwich ELISA Kit is designed for the accurate detection of human Angiotensin-converting enzyme 2 (ACE2) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, with reactivity limited to human samples. The kit is intended for research use only and recognises both natural and recombinant human ACE2 (UniProt Q9BYF1).

Reported performance characteristics include a sensitivity of 0.34 ng/mL and a detection range of 0.78-50 ng/mL, with intra-assay CV of 5.1% and inter-assay CV of 8.7%. Linearity in serum, EDTA plasma and heparin plasma has been validated across serial dilutions, and average recovery is 94% for serum and 96% for plasma.

ACE2 is a key enzyme involved in the renin-angiotensin system, playing a crucial role in regulating blood pressure and cardiovascular function. In the context of microbial infection, the protein acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63. The associated research area is Development Biology, and ACE2 is detected in both the cell membrane and cytoplasm in neurons.