Human and Mouse Phospho-MLKL (S345) PharmaGenie ELISA Kit (SBRS1900)

The Phospho-MLKL (S345) PharmaGenie ELISA Kit from Assay Genie quantitatively measures MLKL phosphorylated at Serine 345, the activating phosphorylation site introduced by RIPK3 during necroptotic cell death. Investigators in inflammation, neurodegeneration, and tumor biology apply this phosphorylation ELISA to track necroptosis engagement in cell lysates and tissue lysates from human samples, with validated cross-reactivity to mouse MLKL. Each kit provides a pre-coated microplate, phospho-specific capture antibody, detection reagent, and recombinant standard for running a full 96-assay plate. Unopened components should be kept frozen at -20 degrees C; reconstituted standards may be aliquoted to limit freeze-thaw cycles and preserve epitope integrity. The assay supports research into TNF-driven necroptosis, viral cell death pathways, and screening of RIPK1/RIPK3 inhibitor compounds.