Human Amyloid beta 1-40 PharmaGenie ELISA Kit (SBRS0248)

The Amyloid beta 1-40 peptide (Aβ1-40) is a 40-residue proteolytic fragment of the amyloid precursor protein (APP) that accumulates in extracellular plaques and cerebral vascular deposits associated with Alzheimer's disease pathology. Quantitative measurement of this species in research samples underpins studies of neurodegeneration, cerebrospinal fluid biomarker panels, secretase inhibitor screening, and longitudinal monitoring of amyloid metabolism in clinical research cohorts.

Assay Genie's PharmaGenie ELISA Kit is configured for 96 assays and delivers a colorimetric readout of human Aβ1-40 across cell culture supernatant, plasma, and serum matrices. The kit supports investigations into γ-secretase and β-secretase cleavage activity, familial versus sporadic Alzheimer's sample comparisons, and differential quantification of Aβ1-40 against the longer Aβ1-42 species that co-aggregate in plaque cores.

Each kit includes the reagents required for a full plate: pre-coated microplate wells, biotinylated detection antibody, calibrated recombinant standard, streptavidin-HRP conjugate, TMB substrate, and wash and stop solutions. Plasma and serum samples should be collected using EDTA or citrate anticoagulation, aliquoted promptly, and stored to limit freeze-thaw exposure, preserving peptide integrity before the assay is performed.