Human AMER1 (APC membrane recruitment protein 1) ELISA KIT (HUFI05456)

The AMER1 protein, also known as WTX (Wilms tumor suppressor on the X chromosome), functions as a scaffold that recruits the tumor suppressor APC to the plasma membrane and modulates beta-catenin signaling through the cytoplasmic destruction complex. Dysregulation of AMER1 has been implicated in Wilms tumor, a pediatric renal malignancy, and in osteopathia striata with cranial sclerosis, where germline mutations disrupt normal Wnt pathway control. Quantitative measurement of AMER1 in research specimens therefore supports studies of Wnt biology, renal oncogenesis, and skeletal developmental disorders.

This Assay Genie immunoassay kit is supplied as a complete set of reagents in a microplate configuration, providing the components required to quantify human AMER1 levels in prepared samples. The kit is configured for research use only and includes pre-coated wells, calibration standards, detection antibodies, and substrate sufficient for the indicated number of determinations. Reconstituted and working reagents should be handled according to the enclosed protocol, with kit components equilibrated to room temperature before use and protected from light where indicated on the datasheet.

AMER1 expression analysis can complement investigations of Wnt dysregulation, where parallel evaluation of beta-catenin, APC, and AXIN levels helps characterize destruction complex integrity. The kit is intended for laboratory research professionals working in cell biology, oncology, and developmental genetics, and supports both hypothesis-driven and screening approaches to AMER1 functional studies.