Human Alpha-2A adrenergic receptor (ADRA2A) ELISA Kit

Assay Genie's Human Alpha-2A adrenergic receptor (ADRA2A) ELISA Kit is a Sandwich ELISA designed for the accurate detection of ADRA2A levels in human samples including serum, plasma, tissue homogenates, cell culture supernatants, and other biological fluids. The kit offers high sensitivity and specificity, ensuring reliable and reproducible results across research applications.

The kit has a sensitivity of 0.078ng/mL with a detection range of 0.156-10ng/mL. Intra-assay precision is reported at 6.0% CV and inter-assay CV at 7.3%. Specificity is directed at the human Alpha-2A adrenergic receptor (UniProt P08913), a multi-pass membrane protein situated at the cell membrane. ADRA2A mediates the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins and, together with the closely related alpha-2B and alpha-2C subtypes, plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

Dysregulation of ADRA2A has been implicated in conditions such as hypertension, anxiety disorders, and attention deficit hyperactivity disorder (ADHD), making it an important target for further research and drug development. For research use only.