Human Alpha-2-Microglobulin Like Protein 1 (a2ML1) ELISA Kit

The Assay Genie immunoassay quantifies Alpha-2-Microglobulin Like Protein 1 (a2ML1), a large secreted glycoprotein of approximately 180 kDa that belongs to the alpha-2-macroglobulin superfamily. The protein contains a conserved internal thiol ester motif shared with complement components C3, C4, and alpha-2-macroglobulin, supporting its role in innate immune surveillance and protease regulation. Research applications include studies of Noonan-spectrum developmental disorders, where heterozygous A2ML1 variants have been reported in affected families, and investigations of epithelial barrier function, since a2ML1 is expressed in skin and mucosal tissues.

Each kit is supplied as a complete configuration sufficient for 96 individual determinations. Reagents are calibrated for absorbance-based readout on a standard microplate reader, with a package insert outlining recommended sample preparation for human-derived biofluid and tissue homogenate inputs. The assay is configured for research use only and supports discovery workflows in immunology, dermatology, and developmental biology laboratories.