Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) ELISA Kit

Manufactured by Assay Genie, this sandwich ELISA kit is designed for the precise measurement of human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) levels in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. It reacts with human samples and is specific for natural and recombinant human ADAMTS4. The quoted detection range is 0.312-20ng/mL, with a sensitivity of 0.092 ng/ml.

ADAMTS4 is described as a key enzyme involved in the breakdown of extracellular matrix proteins, and its dysregulation has been linked to arthritis, cardiovascular disorders, and cancer. The kit is intended for research use only and is associated with the Cell Biology research area. The target protein is secreted and localised to the extracellular space and extracellular matrix, and is reported to interact with SRPX2. By function, ADAMTS4 cleaves aggrecan, a cartilage proteoglycan, and may play an important role in its turnover, with potential involvement in the exacerbation of neurodegeneration in Alzheimer disease. The UniProt reference for the target is O75173.