Human 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) ELISA Kit

Designed for the accurate and precise quantification of human 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) in biological samples, this Sandwich ELISA Kit from Assay Genie is intended for research applications requiring dependable and reproducible results.

The kit uses a colorimetric detection method and is validated for use with serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, with specificity for natural and recombinant human HSD17B10. HSD17B10 plays a crucial role in fatty acid metabolism and mitochondrial function; dysregulation of the protein has been linked to various metabolic disorders, neurodegenerative diseases, and cancer, making it a valuable biomarker for studying these conditions and exploring potential therapeutic targets.

Performance characteristics include a detection range of 0.156-10ng/mL, a sensitivity of 0.087ng/mL, an intra-CV of 6.1% and an inter-CV of 8.9%. Linearity ranges are reported for serum (109-120%, 96-108%, 99-109%, 101-111%), EDTA plasma (103-112%, 103-111%, 110-120%, 101-110%) and heparin plasma (99-108%, 89-99%, 104-117%, 89-101%) at dilutions of 1:2, 1:4, 1:8 and 1:16. Recovery is 101% (range 95-107) for serum and 103% (range 97-109) for plasma. The target protein (Uniprot Q99714) localizes to the mitochondrion, where it functions in mitochondrial tRNA maturation as a component of mitochondrial ribonuclease P. Research Area: Neurosciences. For research use only.