Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) ELISA Kit

This Sandwich ELISA Kit from Assay Genie is designed for the precise measurement of 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) levels in human samples. It is suitable for use with serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay offers a detection range of 0.156-10ng/mL with a sensitivity of 0.1ng/mL, with reported intra-assay CV of 5.7% and inter-assay CV of 8.3%.

PLCG1 is a key enzyme in the phosphoinositide signaling pathway that mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), and plays an important role in the regulation of intracellular signaling cascades. It becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases and contributes to actin reorganization and cell migration. Dysregulation of PLCG1 has been linked to cancer, immune disorders, and neurological conditions, making it a valuable biomarker for research. The kit is specific for natural and recombinant human PLCG1 (Uniprot: P19174), is classed for cardiovascular research, and is intended for research use only.