General Carboxymethyl Lysine (CML) ELISA Kit

An advanced glycation end-product (AGE) formed on long-lived proteins, Carboxymethyl Lysine (CML) is generated through glycoxidative reactions between reducing sugars, dicarbonyl intermediates such as glyoxal, and lysine side chains. It accumulates in tissue and circulates in biological samples, where its concentration serves as a marker of cumulative oxidative stress, glycemic burden, and renal clearance decline. This competitive ELISA kit from Assay Genie supports quantitative CML research across fields including diabetes complications, vascular biology, chronic kidney disease, neurodegenerative studies, and nutritional science focused on dietary AGE intake. The assay format is suited to high-throughput evaluation of cell culture supernatants, animal tissue homogenates, and human biobank samples collected in longitudinal or case-control study designs. Each kit provides pre-coated plates, calibration standards, detection reagents, and buffer concentrates sized for 96 assays per run, together with a detailed step-by-step protocol insert. Researchers studying AGE inhibitors, carbonyl scavengers, antiglycation compounds, or lifestyle interventions can integrate this read-out alongside HbA1c, MDA, or fructosamine measurements to characterize changes in carbonyl stress over time.