Chicken Heme oxygenase 1 (HMOX1) ELISA Kit

This sandwich ELISA from Assay Genie is intended for the detection of Heme oxygenase 1 (Hmox1) in chicken samples, with reactivity specific to chicken. The target corresponds to UniProt entry P14791 and is also known by the synonym HO-1. Dysregulation of Heme oxygenase 1 has been linked to various diseases, including inflammatory conditions, neurodegenerative disorders, and cancer.

Reported performance includes a Detection Range of 0.78-50ng/ml and a Sensitivity of 0.19ng/ml. The kit is validated for use with serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids, and the Specificity covers natural and recombinant chicken Heme oxygenase 1. The target protein has a Molecular Weight of 33,509 Da, a Subcellular Location in the microsome (endoplasmic reticulum), and is associated with the research area of Neurosciences.

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestered and destroyed. The kit is intended for research use only.