XL413 (Hydrochloride), 5 mg

A selective inhibitor of cell division cycle 7 (CDC7) kinase is supplied as the hydrochloride salt by STEMCELL Technologies. The target kinase is involved in the initiation and maintenance of DNA replication. The compound is identified by CAS Number 2062200-97-7, with the chemical formula C14H12ClN3O2 • HCl and a molecular weight of 326.2 g/mol. Reported purity is ≥ 98%, and the full chemical name is 8-chloro-2-(2S)-2-pyrrolidinyl-benzofuro[3,2-d]pyrimidin-4(3H)-one, monohydrochloride.

Published characterization reports an IC50 of 3.4 nM for CDC7 kinase and selectivity over a panel of 100 kinases. Published research describes induction of apoptosis and inhibition of proliferation of human colon adenocarcinoma cells in vitro, as well as attenuation of tumor growth in mice.

The material is supplied as a crystalline solid. It is stable at -20°C as supplied and should be protected from prolonged exposure to light; for long-term storage, a desiccant is recommended. Stability is reported as 12 months from the date of receipt. Reported solubility is ≤ 30 mM in PBS (pH 7.2) and ≤ 613 μM in DMSO. The Safety Data Sheet classifies the substance as not hazardous according to the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) and the Globally Harmonized System (GHS), and lists incompatible materials as strong acids, strong bases, strong oxidizing agents, and strong reducing agents.