(+)-MK-801 (Hydrogen Maleate), 10 mg

A research-grade small molecule offered by STEMCELL Technologies, this compound is a neuroprotective agent and a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with a reported binding affinity of Ki = 30.5 nM. The NMDA receptor is a calcium-permeable ion channel found in neurons, regulated by its ligands glutamate and glycine, and its signaling is involved in plasticity, cell survival, and cell death. Hyperactivity of these receptors can result in neuron loss and may contribute to neurodegenerative diseases.

Also known by the alternative name Dizocilpine, the substance is supplied as a crystalline solid. Its chemical formula is C16H15N • C4H4O4, with a molecular weight of 337.4 g/mol and a purity of ≥ 98%. It is soluble in DMSO (≤ 55 mM) and in absolute ethanol (≤ 1.4 mM), but has low solubility in aqueous media. The product is stable at -20°C as supplied and should be protected from prolonged exposure to light; for long-term storage, use of a desiccant is recommended. It remains stable as supplied for 12 months from the date of receipt.

Among its published research applications, the compound has been shown to protect against neuron loss in rat striatum and hippocampus. It is intended for research use only and is not for human or animal diagnostic or therapeutic use unless otherwise stated. For use as a cell culture supplement, the stock solution should be diluted into culture medium immediately before use, with a final DMSO concentration above 0.1% avoided due to potential cell toxicity.