(S)-MG132, 1 mg

From STEMCELL Technologies, this small molecule is a reversible, cell-permeable inhibitor of proteasome activity (IC₅₀ = 100 nM) and calpain (IC₅₀ = 1.2 µM). It suppresses NF-κB activation by preventing IκB degradation (IC₅₀ = 3 µM) and is also described as a hypoxia inducible factor-1α (HIF1α) inhibitor with anti-inflammatory properties.

The compound is supplied as a crystalline solid with a molecular formula of C₂₆H₄₁N₃O₅ and a molecular weight of 475.6 g/mol. Purity is ≥ 98%, and the chemical is identified by CAS number 133407-82-6. Alternative names include Calpain inhibitor IV-2 and Z-Leu-Leu-Leu-CHO. Solubility is reported at ≤ 60 mM in DMSO and ≤ 50 mM in absolute ethanol; the compound has low solubility in aqueous media, and a final DMSO concentration above 0.1% should be avoided due to potential cell toxicity. The product is stable at -20°C as supplied, should be protected from prolonged exposure to light, and remains stable for 12 months from the date of receipt.

Published research applications include blocking apoptosis triggered by DNA damage in HeLa cells, inhibiting NF-κB activation to sensitize a variety of carcinoma cell lines to apoptosis, producing cytotoxic effects on a variety of human cancer cell lines, and inhibiting the growth of mouse melanoma (B16) and human ocular melanoma (IPC227F) cell lines. For research use only.