XAV939, 10 mg

A potent small molecule WNT pathway inhibitor from STEMCELL Technologies, this compound—chemically 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one—selectively inhibits tankyrase (TNKS) 1 and 2, with reported IC₅₀ values of 11 nM and 4 nM, respectively. By blocking tankyrase activity, it stabilizes the AXIN-GSK3β degradation complex, promoting β-catenin degradation in SW480 cells and suppressing downstream WNT signaling.

It is supplied as a crystalline solid with a molecular weight of 312.3 g/mol and chemical formula C₁₄H₁₁F₃N₂OS (CAS 284028-89-3). Purity is ≥ 98%. Solubility in DMSO is ≤ 6.4 mM; for example, 1 mg can be resuspended in 3.20 mL of DMSO to yield a 1 mM stock solution. The product is stable at -20°C as supplied, should be protected from prolonged exposure to light, and is reported as stable for 12 months from date of receipt. The compound has low solubility in aqueous media.

Published research applications include induction of cardiomyogenesis in mesoderm progenitor cells derived from mouse embryonic stem cells, and—in combination with the SMAD inhibitors LDN193189 and SB431542—promotion of forebrain fate induction in human pluripotent stem cell lines. In cancer research, it inhibits colony formation of APC-deficient, β-catenin-dependent DLD-1 colorectal cancer cells. This product is for research use only and is not intended for human or animal diagnostic or therapeutic uses.