WHI-P131 , 10 mg

A selective cell-permeable JAK3 (Janus kinase 3) inhibitor supplied as a 10 mg powder vial, WHI-P131 is a quinazoline-derived small molecule used to interrogate cytokine-driven signal transduction in T-cell biology. The compound blocks IL-2-induced JAK3-mediated STAT5 phosphorylation, making it a standard probe in studies of lymphocyte activation, immune regulation, and kinase signaling pathways.

Researchers use it in cell culture and in vitro assays to characterize JAK/STAT-dependent transcription, model autoimmune mechanisms, and evaluate kinase inhibition in hematological malignancy lines. For reconstitution, dissolve in DMSO before dilution into aqueous working buffers; store the powder at -20 degrees C, protected from light and moisture, and aliquot to limit freeze-thaw cycling.

STEMCELL Technologies provides this research use only reagent for laboratories investigating transplant tolerance, inflammatory disease models, and STAT-linked transcriptional responses. Working concentrations typically fall in the low micromolar range, optimized per cell line and endpoint.