Vps34-IN1, 1 mg

Supplied as 1 mg of lyophilized powder in a single vial, this selective Vps34 inhibitor from STEMCELL Technologies blocks class III phosphatidylinositol 3-kinase (PIK3C3), a lipid kinase that drives autophagosome biogenesis and endosomal trafficking. Researchers apply the compound to mammalian cell culture models to dissect autophagy regulation, characterize mTOR-independent nutrient sensing, and study class III PI3K signaling in cancer cell lines. The reagent is intended for in vitro research use only.

Investigators dissolve the powder in DMSO to prepare concentrated stock solutions, then treat cells at low micromolar working concentrations to suppress LC3 lipidation and block autophagic flux. Beyond autophagy assays, the inhibitor is useful for probing VPS34-dependent endosomal sorting and for examining the contribution of PIK3C3 activity to tumor cell survival pathways. The lyophilized format supports stable storage at -20 °C, protected from light and moisture, for use across multiple experimental sessions.