Vandetanib, 10 mg

A laboratory chemical supplied by STEMCELL Technologies as a crystalline solid for research use. The substance is identified by the chemical name N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine (CAS 443913-73-3) and is also known by the synonyms ZD 6474, Zactima, CH 331, and Caprelsa. It has a molecular formula of C22H24BrFN4O2 and a molecular weight of 475.4.

The product is classified under the 2012 OSHA Hazard Communication Standard as acutely toxic if swallowed (Category 4), a reproductive toxicant (Category 1B), and a specific target organ toxicant upon repeated exposure (Category 2). Hazard statements indicate it is harmful if swallowed, may damage fertility or the unborn child, may cause damage to organs through prolonged or repeated exposure, and is very toxic to aquatic life with long lasting effects. It is supplied as 100% of the active substance, and the material is reported to be chemically stable.

Solubility is reported at approximately 0.5 mg/mL in 1:1 DMF:PBS (pH 7.2) and approximately 2 mg/mL in DMSO and DMF. Recommended personal protective equipment includes safety glasses, compatible chemical-resistant gloves, and a lab coat, with a NIOSH- or CEN-approved respirator as conditions warrant. The product is intended for laboratory chemical use only and is not for human or animal diagnostic or therapeutic use. In case of emergency, contact 1-800-667-0322.