Tunicamycin, 5 mg

A nucleoside antibiotic and N-acetylglucosamine phosphotransferase inhibitor supplied by STEMCELL Technologies. In addition to inhibiting N-linked glycosylation, the compound also inhibits protein palmitoylation. It can be used to induce the unfolded protein response and to investigate the mechanism of autophagy.

The molecular weight is 845.0 g/mol, with a chemical formula of C39H64N4O16 (Tunicamycin VII). The CAS number is 11089-65-9, and purity is ≥ 95% (mixture of congeners). The product is a crystalline solid that is stable for 12 months from date of receipt when stored at -20 °C and protected from prolonged exposure to light. For long-term storage, store with a desiccant.

Solubility information indicates the product is soluble in DMSO at ≤ 20 mM. For use as a cell culture supplement, the stock solution should be diluted into culture medium immediately before use, and final DMSO concentration should be kept below 0.1% due to potential cell toxicity. Published applications include radiosensitization of human pancreatic cancer cells to chemotherapy and induction of endoplasmic reticulum stress and autophagy in cancer cells. The product is for research use only and is not intended for human or animal diagnostic or therapeutic uses. The product is hazardous; please refer to the Safety Data Sheet (SDS).