Torin 2, 5 mg

Torin 2 is a highly selective, ATP-competitive small molecule inhibitor of mTOR (mammalian target of rapamycin) kinase, widely used in cell signaling and cancer research. Supplied by STEMCELL Technologies as a 5 mg solid powder, it is a second-generation analog refined from Torin 1 with substantially improved potency and selectivity. The compound inhibits both mTORC1 and mTORC2 complexes with an IC50 of approximately 0.25 nM, and at higher concentrations it also blocks related PIKK family kinases such as PI3K, ATM, ATR, and DNA-PK. Researchers commonly employ this compound in cell culture to study autophagy induction, cap-dependent translation, growth arrest, and apoptotic pathways across diverse cancer cell lines and primary cells. The compound is soluble in DMSO and is stored at -20 °C, protected from light, with handling under inert atmosphere recommended for long-term stability. Published studies report effective working concentrations in the 10 nM to 250 nM range depending on cell type and application. Packaged in a single vial, this reagent is intended for research use only and is not approved for diagnostic or therapeutic applications.