Torin 2, 10 mg

A potent, selective, and ATP-competitive small-molecule inhibitor of mTOR kinase, supplied at 10 mg per vial for cell biology and oncology research applications. Torin 2 enables researchers to dissect mTOR-dependent signaling pathways, block cap-dependent translation, and induce autophagy in cultured mammalian cells, with cellular activity reported at low nanomolar concentrations. The compound also inhibits related PIKK-family kinases including ATM, ATR, and DNA-PKcs, making it a useful tool for studying DNA damage response crosstalk with mTOR signaling. Working concentrations in cell culture commonly fall in the 10 to 250 nM range, depending on cell type and assay endpoint, and stock solutions are typically dissolved in DMSO. The product is intended for research use only and is supplied as a solid powder in a single-use vial; store at -20°C, protected from light, to preserve inhibitor activity across freeze-thaw cycles. STEMCELL Technologies provides this reagent as part of its small-molecule toolbox for autophagy, cell signaling, and cancer pathway research.