Torin 1, 50 mg

An ATP-competitive inhibitor of the mammalian target of rapamycin (mTOR), Torin 1 inhibits the mTOR complexes mTORC1 and mTORC2 with IC₅₀ values of 2 and 10 nM, respectively. It is selective for mTOR versus a panel of over 400 other kinases screened at 10 µM (Thoreen et al.; Liu et al.).

In published cancer research, Torin 1 inhibits tumor growth, likely through a cytostatic rather than cytotoxic mechanism, in a U87MG PTEN-null glioblastoma mouse xenograft model (Liu et al.). It also hinders growth, motility, invasion, and survival of primary colon cancer stem-like cells in vitro, and suppresses tumor growth without affecting normal colon stem cells in xenografts (Francipane & Lagasse).

Supplied by STEMCELL Technologies as a crystalline solid with a purity of ≥ 95%, the compound has a chemical formula of C₃₅H₂₈F₃N₅O₂, a molecular weight of 607.6 g/mol, and CAS Number 1222998-36-8. The product is stable at -20°C as supplied for 12 months from date of receipt, with protection from prolonged exposure to light recommended.