Thapsigargin, 1 mg

A cell-permeable sesquiterpene lactone from STEMCELL Technologies that acts as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases (SERCAs) and has been shown to induce autophagy in mammalian cells. The compound has a molecular weight of 650.8 g/mol and a chemical formula of C34H50O12 (CAS Number: 67526-95-8), with a purity of ≥ 97%.

Thapsigargin is supplied as a crystalline solid and is recommended for use as a laboratory chemical. Published research applications include inducing apoptosis in thymocytes in rats and inducing endoplasmic reticulum stress and autophagy in mammalian cells. The product is stable at -20°C as supplied and should be protected from prolonged exposure to light; it is stable as supplied for 12 months from date of receipt.

Reported solubilities are ≤ 45 mM in DMSO and ≤ 45 mM in absolute ethanol, with the compound having low solubility in aqueous media. The safety data sheet classifies the substance as causing skin irritation, serious eye irritation, respiratory sensitization, and respiratory irritation.