SU5402, 5 mg

A small molecule research reagent from STEMCELL Technologies, SU5402 is described as a potent and selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor beta (PDGFRB), with reported IC₅₀ values of 0.02, 0.03, and 0.51 µM, respectively. It is identified as a MEK/ERK pathway inhibitor and is referenced as a tyrosine kinase inhibitor.

The compound (CAS 215543-92-3) carries the chemical name 2-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid, with molecular formula C₁₇H₁₆N₂O₃ and molecular weight 296.3 g/mol. It is supplied as a crystalline solid with a stated purity of ≥95%. Reported solubility values are ~0.5 mg/mL in a 1:1 solution of DMSO:PBS (pH 7.2), ~30 mg/mL in DMSO, and ~5 mg/mL in DMF.

STEMCELL Technologies highlights published research applications including support of long-term embryonic stem cell propagation when used in combination with leukemia inhibitory factor, inhibition of mouse B cell growth and survival, and induction of apoptosis in human multiple myeloma cell lines. The product is stable at -20°C as supplied for 12 months from the date of receipt, with stock solutions recommended in DMSO at ≤100 mM. It is intended for research use only and not for human or animal diagnostic or therapeutic uses.