SU11274, 1 mg

STEMCELL Technologies offers a selective, ATP-competitive inhibitor of the c-MET receptor tyrosine kinase, designated SU11274. The compound shows an IC₅₀ of 20 nM against c-MET (Sattler et al.), with reduced activity against other receptor tyrosine kinases: IC₅₀ values of 1.3 µM for the kinase insert domain receptor (KDR/FLK-1) and 9.7 µM for fibroblast growth factor receptor-1 (FGFR-1). It retains activity against certain c-MET mutants, including H1112Y and M1268T (Berthou et al.).

In cancer research applications, the compound induces apoptosis and cell cycle arrest in TPR-MET-transformed mouse pre-B (Ba/F3) cells (Sattler et al.), inhibits cell viability and motility of human head and neck squamous cell carcinoma cell lines in vitro (Seiwert et al.), and inhibits cell viability of c-MET-expressing human non-small cell lung carcinoma cell lines in vitro (Ma et al.).

Chemical properties include a CAS number of 658084-23-2, a chemical formula of C₂₈H₃₀ClN₅O₄S, and a molecular weight of 568.1 g/mol. Also known as Met Kinase Inhibitor, the compound targets the HGF pathway and is supplied as a crystalline solid.