StemRegenin 1, 5 mg

A small-molecule compound supplied by STEMCELL Technologies, StemRegenin 1 (also known as SR1) acts as an antagonist of the aryl hydrocarbon receptor (AHR) and is used to promote the maintenance and expansion of human hematopoietic stem cells in culture. It is intended for laboratory use, including serum-free workflows for the culture and expansion of hematopoietic cells.

The active substance is 4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol (CAS No. 1227633-49-9), with a molecular weight of 429.5 and a molecular formula of C24H23N5OS. It is supplied as a crystalline solid. Reported solubility values are approximately 0.25 mg/mL in a 1:3 solution of DMF:PBS (pH 7.2), approximately 11 mg/mL in DMSO, and approximately 13 mg/mL in DMF.

The compound is classified as harmful if swallowed, causing skin irritation, serious eye irritation, and may cause respiratory irritation. Recommended handling precautions include the use of impervious gloves, eye/face protection, long-sleeved clothing, and adequate ventilation.