Sirtinol, 10 mg

A cell-permeable small molecule supplied by STEMCELL Technologies that inhibits sirtuin NAD+-dependent histone deacetylases, acting on yeast Sir2p (IC50 = 68 µM), human SIRT1 (IC50 = 131 µM), and human SIRT2 (IC50 = 38 µM). It does not inhibit human HDAC1 activity and also activates the auxin signaling pathway in Arabidopsis.

The compound has the chemical formula C₂₆H₂₂N₂O₂ and a molecular weight of 394.5 g/mol, with a reported purity of ≥ 98%. It is a crystalline solid, stable at -20°C as supplied; prolonged light exposure should be avoided and long-term storage with a desiccant is recommended. Solubility in DMSO is reported at ≤ 25 mM, with low aqueous solubility; for cell culture use, DMSO stock solutions should be diluted into medium immediately before use, keeping final DMSO concentrations below 0.1%.

Published applications include suppression of inflammatory signaling in human dermal microvascular endothelial cells (immunology), enhancement of apoptosis and cell death in leukemic cells while sparing healthy leukocytes and hematopoietic progenitors, and induction of senescence-like growth arrest in human cancer cell lines MCF-7 and H1299 (cancer research). The product is for research use only and is classified as hazardous, with users directed to the Safety Data Sheet.