SB431542, 25 mg

From STEMCELL Technologies, this laboratory chemical is a selective and potent inhibitor of the TGF-beta/Activin/Nodal pathway, inhibiting ALK5, ALK4, and ALK7. It is supplied as a solid with a crystalline appearance and is identified by the synonym SB-431542. The chemical name is 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, with a molecular weight of 384.4 and a molecular formula of C22H16N4O3 • XH2O.

According to the manufacturer's Safety Data Sheet, the compound is not considered a hazardous substance or mixture according to the Globally Harmonized System (GHS). It is stable under recommended transport or storage conditions, and no incompatible materials are known. Reported solubilities include approximately 0.5 mg/mL in a 1:1 solution of DMSO:PBS (pH 7.2), approximately 2 mg/mL in EtOH, and approximately 20 mg/mL in DMF and DMSO.

For safe use, handle in accordance with good industrial hygiene and safety practice, store per the Product Information Sheet, and ensure adequate ventilation. The supplier's emergency telephone line is 1-800-667-0322.