SB431542, 10 mg

From STEMCELL Technologies, SB431542 (Hydrate) is a selective and potent inhibitor of the TGF-beta/Activin/Nodal pathway. It acts as an Activin/BMP/TGF-β pathway inhibitor that inhibits ALK5, ALK4, and ALK7.

The compound has the synonym 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, with CAS number 301836-41-9, molecular formula C22H16N4O3, and molecular weight 384.40. It appears as a crystalline solid and is reported soluble at ~0.5 mg/mL in 1:1 DMSO:PBS (pH 7.2), ~2 mg/mL in EtOH, and ~20 mg/mL in DMF and DMSO. According to its safety data sheet, the chemical is stable, not classified as hazardous under GHS, and is not regulated as dangerous goods under DOT, ADR/RID, IMDG, or IATA.

This product is for research use only and is not intended for human or animal diagnostic or therapeutic uses.