SB431542, 1 mg

A selective small-molecule research reagent supplied by STEMCELL Technologies, the hydrate form of 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide is described as a potent inhibitor of the TGF-β/Activin/Nodal pathway, acting on the ALK5, ALK4, and ALK7 receptors. It is supplied as a crystalline solid and is referenced as an Activin/BMP/TGF-β pathway inhibitor in research applications.

According to the manufacturer's Safety Data Sheet, the substance is not classified as hazardous under GHS, with CAS number 301836-41-9 and a molecular formula of C22H16N4O3 (molecular weight 384.40). Reported solubility values include approximately 0.5 mg/mL in 1:1 DMSO:PBS (pH 7.2), about 2 mg/mL in ethanol, and approximately 20 mg/mL in DMF and DMSO. The compound is chemically stable; incompatible materials include strong acids and strong bases, with hazardous decomposition products listed as carbon dioxide, carbon monoxide, and nitrogen oxides.

The product is intended for research use only and is not approved for human or animal diagnostic or therapeutic applications. Recommended personal protective equipment includes safety glasses, compatible chemical-resistant gloves, and a lab coat, with a NIOSH- or CEN-approved respirator as conditions warrant. The container should be kept tightly closed and stored in accordance with the product insert.