SAHA, 500 mg

From STEMCELL Technologies, this small molecule is a potent inhibitor of class I and class II histone deacetylases (HDACs), with reported activity against HDAC1 and HDAC3 (IC50 = 10 nM and 20 nM, respectively; Richon et al.). The compound exhibits antiproliferative properties and can induce cell cycle arrest at G1 (Marks & Breslow). It is also known as suberoylanilide hydroxamic acid, Vorinostat, and Zolinza®.

With a chemical name of N-Hydroxy-N'-phenyloctanediamide, the product has a molecular formula of C14H20N2O3, a molecular weight of 264.3 g/mol, and a reported purity of ≥ 98%. It is supplied as a crystalline solid. Recommended solubility is ≤ 75 mM in DMSO and ≤ 0.9 mM in absolute ethanol. The product is stable at -20°C as supplied and should be protected from prolonged light exposure; for long-term storage, store with a desiccant.

Published applications include improving reprogramming efficiency from human and mouse somatic cells to induced pluripotent stem cells (Huangfu et al.); downregulating homologous recombination and promoting apoptosis in ovarian cancer cells when combined with olaparib (Konstantinopoulos et al.); and downregulating Nanog expression, which leads to inhibition of proliferation in head and neck cancer stem cells (Kumar et al.). According to the safety data sheet, the compound is classified as a Category 2 germ cell mutagen and Category 1B reproductive toxicant, and is suspected of causing genetic defects and may damage fertility or the unborn child. It is for research use only.