(S)-MG132, 10 mg

Offered by STEMCELL Technologies, this compound is documented in the manufacturer's safety literature under the synonyms Calpain inhibitor IV-2 and Z-Leu-Leu-Leu-CHO. The substance is identified by CAS number 133407-82-6 and has the molecular formula C26H41N3O5 with a molecular weight of 475.6. It is described by the manufacturer as an inhibitor of NF-κB and the ubiquitin-proteasome, with reported cytotoxic effects on cancer cells, and is additionally listed as a Hypoxia inducible factor-1α (HIF1α) inhibitor and an anti-inflammatory NF-κB pathway inhibitor. The material is a crystalline solid with reported solubility of ~25 mg/mL in EtOH and ~30 mg/mL in DMSO and DMF. It is intended for laboratory use, with handling and storage conditions detailed in the Product Information Sheet.