(±)-Nutlin-3, 1 mg

A p53 inhibitor supplied by STEMCELL Technologies as a crystalline solid. The active substance is (±)-Nutlin-3, with CAS number 548472-68-0, molecular formula C30H30Cl2N4O4, and molecular weight 581.5. According to the manufacturer, (±)-Nutlin-3 promotes transcription of p53-regulated genes by disrupting the inhibitory interaction of MDM2 with p53. The product is recommended for laboratory chemical use.

Solubility data from the manufacturer's safety data sheet indicate 20 mg/mL in DMSO and 50 mg/mL in ethanol. The substance is classified under the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) as causing skin irritation (Category 2), serious eye irritation (Category 2A), and may cause respiratory irritation (Category 3, single exposure). Recommended handling precautions include wearing protective gloves and eye/face protection, using only in a well-ventilated area, and avoiding breathing dust or vapors. The chemical is stable under recommended transport and storage conditions; strong oxidizing agents are listed as incompatible materials.