PluriSIn-1, 50 mg

This small molecule from STEMCELL Technologies is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase (SCD1), a key enzyme for lipid metabolism expressed in human pluripotent stem cells. The compound selectively eliminates undifferentiated human embryonic stem (ES) and induced pluripotent stem (iPS) cells while sparing differentiated cells, and has been shown to prevent teratoma formation in transplanted mice. It also induces apoptosis of Nanog-positive iPS cells in vitro while leaving iPS cell-derived cardiomyocytes unaffected.

The chemical formula is C₁₂H₁₁N₃O, with a molecular weight of 213.2 g/mol and a purity of ≥ 95%. Alternative names include N'-phenyl-hydrazine-Isonicotinic acid and NSC 14613, and the CAS Number is 91396-88-2.