NU7441, 5mg

A research-grade laboratory reagent supplied by STEMCELL Technologies, this product is a small-molecule inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. The compound, also known by the synonym KU57788, is the single-component substance 8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one (CAS No. 503468-95-9) with a molecular weight of 413.5 and a molecular formula of C25H19NO3S. It is presented as a crystalline solid and is intended for use as a laboratory chemical.

Reported solubility values are 1 mg/mL in DMF, 0.2 mg/mL in DMF:PBS (pH 7.2) at a 1:4 ratio, and 0.12 mg/mL in DMSO. The product is not classified as a hazardous substance or mixture under the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) or the Globally Harmonized System (GHS), and it is not regulated for transport by DOT, TDG, MEX, ICAO, IATA, IMDG, RID, ADR, or ADN. It is stable under recommended transport and storage conditions and should be stored in accordance with the Product Information Sheet; strong oxidizing agents are listed as incompatible materials. In case of eye contact, rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids, and consult a physician. The supplier, STEMCELL Technologies Canada Inc., can be reached at the emergency telephone number provided on the safety data sheet.