NBQX (Sodium Salt), 10 mg

A potent, competitive AMPA receptor antagonist supplied as a crystalline solid by STEMCELL Technologies. NBQX (Sodium Salt) is described as a neuroprotective compound referenced in research on nervous system function, learning and memory, and neurological disease, with published reports of reduced cerebral ischemic necrosis in the hippocampus.

The chemical name is 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide, disodium salt (CAS 479347-86-9), with molecular formula C12H6N4O6S • 2Na, molecular weight 380.2 g/mol, and a reported purity of ≥ 98%. An IC50 of 0.15 μM is cited from Sheardown et al. for AMPA receptor antagonism.

The Safety Data Sheet classifies the substance for skin corrosion/irritation (Category 2), serious eye damage/eye irritation (Category 2A), and specific target organ toxicity (single exposure, Category 3), with hazard statements indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. The product is not flammable and is incompatible with strong oxidizing agents; hazardous decomposition products include carbon oxides, nitrogen oxides, and sulfur oxides. Storage recommendations call for keeping the product at -20 °C as supplied, protected from prolonged light exposure, and stored with a desiccant for long-term use. It is reported as stable as supplied for 12 months from date of receipt. Solubility is reported as ≤ 50 mM in DMSO and the compound is insoluble in water; the SDS additionally lists DMF at 1 mg/mL and DMSO at 20 mg/mL.