MK0457, 250 mg

A laboratory chemical supplied by STEMCELL Technologies as a crystalline solid. The substance is formally identified as N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide and is also known by the synonyms Tozasertib and VX 680. It has the molecular formula C23H28N8OS and a molecular weight of 464.6, with CAS number 639089-54-6.

According to the manufacturer's safety documentation, the compound is stable under normal conditions. Reported solubility values are approximately 0.1 mg/mL in a 1:10 solution of DMF:PBS (pH 7.2) and approximately 15 mg/mL in DMSO and DMF. A 2015 safety data sheet classified the material with GHS hazard statements including H300 (fatal if swallowed), H315 (causes skin irritation), H318 (causes serious eye damage), H361 (suspected of damaging fertility or the unborn child) and H373 (may cause damage to organs through prolonged or repeated exposure); a later 2021 revision states the chemical is not classified as hazardous according to the 2012 OSHA Hazard Communication Standard.