ME0328, 5 mg

A selective small-molecule inhibitor supplied at 5 mg per vial by STEMCELL Technologies for research applications in stem cell biology and oncology studies. The compound targets aldehyde dehydrogenase 1A1 (ALDH1A1) with high isoform selectivity over ALDH2 and ALDH3A1, and additionally inhibits casein kinase 1 isoforms CK1δ and CK1ε, allowing researchers to probe retinoic acid biosynthesis and CK1-mediated phosphorylation events within parallel workflows.

ME0328 is supplied as a lyophilized powder suitable for reconstitution in DMSO prior to use in vitro in cell culture. Recommended storage is at -20 °C, protected from light, and single-use aliquots are advised to limit freeze-thaw exposure of the active material. Working concentrations commonly cited in published protocols fall in the low micromolar range for ALDH activity assays and CK1 kinase inhibition.

Typical applications include characterization of hematopoietic and neural stem cell populations where ALDH1A1 activity serves as a functional marker, differentiation studies using retinoic acid pathway modulation, and investigation of cancer stem cell phenotypes. The 5 mg pack size provides sufficient material for routine dose-response work, western blot validation, and flow cytometry-based ALDH activity assays. For research use only; not for diagnostic or therapeutic applications.