LY411575, 25 mg

A cell-permeable γ-secretase inhibitor with an IC₅₀ of 0.14 nM, this crystalline solid from STEMCELL Technologies has been shown to block Notch activation in vitro at 500 µM. With the molecular formula C₂₆H₂₃F₂N₃O₄, a molecular weight of 479.5 g/mol, CAS number 209984-57-6, and a reported purity of ≥ 98%, it is not classified as a hazardous substance or mixture according to the Globally Harmonized System (GHS).

Published research applications include promotion of neuronal differentiation of neural progenitor cells derived from mouse embryonic stem cells, goblet cell differentiation in mouse intestine and cultured colonic organoids, and hair cell differentiation from inner ear stem cells in vitro. The compound has also been reported to induce apoptosis in primary and immortalized Kaposi's sarcoma tumor cells.

The product is stable at -20°C as supplied and should be protected from prolonged exposure to light, remaining stable for 12 months from the date of receipt. Reported solubilities include DMF at 10 mg/mL, with recommended upper limits of ≤ 200 µM in DMSO, ≤ 200 µM in absolute ethanol, and ≤ 20 mM in DMF. The compound has low solubility in aqueous media, and for cell culture use, stock solutions should be diluted into culture medium immediately before use, avoiding final DMSO concentrations above 0.1%.