LY364947, 5 mg

From STEMCELL Technologies, this small molecule acts as a selective inhibitor of the TGF-β/Activin/NODAL signaling pathway, with its primary biochemical target being the kinase ALK5. Reported IC₅₀ values (Sawyer et al.) are 59 nM for ALK5, 400 nM for TGFβRII, 740 nM for p38 MAPK, and 1,400 nM for mixed lineage kinase-7 (MLK-7), as documented by Li et al. (2006) and Sawyer et al.

In cell reprogramming, the compound has been shown, in combination with valproic acid, to substitute for SOX2 in the reprogramming of mouse embryonic fibroblasts transduced with OCT4, KLF4, and c-MYC (Ichida et al.). The manufacturer positions the product for use in research areas covering reprogramming, differentiation, and cancer research.