LRRK2-IN-1, 5 mg

A laboratory chemical from STEMCELL Technologies, LRRK2-IN-1 (synonym: Leucine-rich repeat kinase 2 IN-1) is described by the manufacturer as an inhibitor of LRRK2. The compound is identified by CAS No. 1234480-84-2 and carries the chemical name 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, a molecular formula of C31H38N8O3 and a molecular weight of 570.7.

In its supplied form, the material is a solid with a crystalline appearance. The Safety Data Sheet reports solubility values of 0.5 mg/mL in a 1:1 solution of EtOH:PBS (pH 7.2), 25 mg/mL in EtOH, 16 mg/mL in DMSO, and 20 mg/mL in DMF. The chemical is not classified as hazardous under the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) and is stable under normal conditions. Strong oxidizing agents are listed as incompatible materials, and hazardous decomposition products include carbon dioxide (CO2), carbon monoxide, and nitrogen oxides (NOx).

Storage should follow the instructions on the Product Information Sheet (PIS). The product is not regulated for transport by DOT, TDG, MEX, ICAO (air), IATA, IMDG, RID, ADR, or ADN. It is supplied by STEMCELL Technologies Canada Inc., based in Vancouver, British Columbia, Canada.