JIB-04, 10 mg

A selective, irreversible small-molecule inhibitor of the Jumonji C (JmjC) domain-containing histone demethylase family, this research-grade compound enables laboratories to dissect histone methylation dynamics in cancer biology, stem cell differentiation, and transcriptional regulation studies. The molecule is widely deployed in cell-based assays and in vivo tumor models to suppress demethylase activity of KDM4 and KDM5 subfamily members at sub-micromolar concentrations.

JIB-04 from STEMCELL Technologies is supplied as 10 mg of solid powder in a single vial, intended for in vitro research use. Published work demonstrates that the compound reduces global H3K9me3 and H3K36me3 marks and slows tumor cell proliferation without broadly affecting DNA methylation levels. Researchers typically reconstitute the powder in DMSO to prepare concentrated stock solutions for routine cell culture workflows, and the pan-demethylase inhibition profile makes it a useful tool for comparative studies between individual KDM isoforms.

Store the unopened vial at -20°C protected from light and moisture, and aliquot reconstituted DMSO stocks to minimize freeze-thaw cycles across repeated experiments.