JAK Inhibitor I, 1 mg

STEMCELL Technologies supplies a small-molecule Janus Associated Kinase (JAK) inhibitor that disrupts JAK activity by interacting with the ATP binding domain. The compound is a crystalline solid and is also known by the synonyms CMP 6, Janus-associated kinase inhibitor I, and Pyridone 6.

Chemically, the active substance is 2-(1,1-dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one (CAS No. 457081-03-7), with the molecular formula C18H16FN3O and a molecular weight of 309.3. Reported solubility values are ~0.3 mg/mL in a 1:2 solution of DMSO:PBS (pH 7.2), ~1 mg/mL in EtOH, and ~15 mg/mL in DMSO and DMF.

The inhibitor is described as a tyrosine kinase inhibitor that inhibits EGFR, HER2, JAK2, JAK3 and STAT5a/b, and as a JAK/STAT pathway inhibitor that inhibits JAK1, JAK2, and STAT5. It is intended for use as a laboratory chemical, and STEMCELL Technologies recommends storing it in accordance with the Product Information Sheet.