IWP-4, 10 mg

Used as a research tool for studying Wnt-driven developmental processes, this Porcupine (Porcn) inhibitor from STEMCELL Technologies blocks palmitoylation of Wnt ligands, preventing their secretion and silencing downstream signaling. The compound is supplied as a 10 mg solid suitable for stem cell biology, organoid culture, and directed differentiation protocols.

In intestinal, hepatic, and cerebral organoid systems, controlled attenuation of Wnt signaling is required to drive specific lineage commitment, and IWP-4 is widely adopted for this purpose. The inhibitor also features in cardiac differentiation workflows for pluripotent stem cells, where suppressing Wnt activity during early mesoderm patterning is critical. The powder format allows precise weighing and reconstitution in DMSO before dilution into aqueous culture media.

For storage, keep the unopened vial at -20 °C, protected from light, and aliquot after reconstitution in DMSO to limit freeze-thaw cycles. Working stocks remain stable for several weeks at -20 °C. The 10 mg pack size supports laboratories running multiple differentiation experiments or maintaining long-term organoid cultures.