IWP-3, 10 mg

Supplied by STEMCELL Technologies, this small molecule is an inhibitor of WNT signaling. It inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating WNT proteins, a modification essential for their signaling ability and secretion. The compound impairs WNT pathway activity in vitro with an IC₅₀ value of 40 nM.

Key properties include CAS Number 687561-60-0, Chemical Formula C₂₂H₁₇FN₄O₂S₃, Molecular Weight 484.6 g/mol, and Purity ≥ 98%. The material is supplied as a crystalline solid. For storage, the product is stable at -20°C as supplied and should be protected from prolonged exposure to light; it remains stable as supplied for 12 months from date of receipt. Reported solubility limits are DMSO ≤ 200 µM and dimethylformamide (DMF) ≤ 4.1 mM.

In published applications, the compound promotes cardiomyocyte differentiation from human embryonic stem cells that have been induced to mesoderm by addition of BMP-4 and Activin A.