ID-8, 5 mg

A small-molecule inhibitor of the dual-specificity tyrosine-phosphorylation-regulated kinases DYRK1A and DYRK1B, this 5 mg formulation from STEMCELL Technologies is supplied as lyophilized powder for stem cell research applications. The compound supports the maintenance of human pluripotent stem cells in culture and is frequently incorporated into feeder-free workflows as an alternative or supplement to ROCK pathway inhibitors. Researchers commonly add this reagent to mTeSR or E8 media to improve colony survival during routine passaging, single-cell dissociation, and cryobanking of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs). It has also been used in 3D organoid maintenance protocols where its kinase-selective activity helps stabilize proliferative progenitors during long-term expansion. Each vial is intended for in vitro research use only and should be stored desiccated at -20 °C, protected from light to preserve activity. The 5 mg unit provides ample material for tens of experiments at standard working concentrations in the low micromolar range, and the product is shipped as a single-use research reagent for cell culture applications.