Honokiol, 50 mg

STEMCELL Technologies supplies a small molecule identified as a natural lignan derived from the plant Magnolia grandiflora. The compound, also referenced by the alternative name NSC-293100, bears the chemical name 3',5-Diallyl-[1,1'-biphenyl]-2,4'-diol and is identified by CAS Number 35354-74-6. Its chemical formula is C18H18O2, with a molecular weight of 266.3 g/mol, and the material is provided as a beige powder at a stated purity of ≥ 98%.

Honokiol, the active component, exhibits antineoplastic and neuroprotective properties. It inhibits the phosphorylation of Akt, a protein kinase involved in regulating the production of inflammatory molecules, and demonstrates anti-inflammatory activity by suppressing nuclear factor kappa B (NF-κB) activation along with the production of inflammatory factors such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), and RANTES/CCL5 in glial cells.

For handling, the product is stable at -20°C as supplied; STEMCELL recommends storing small molecules away from direct light, with long-term storage alongside a desiccant. The compound remains stable as supplied for 12 months from date of receipt and is soluble in DMSO at ≤ 185 mM. Published research applications include cancer research—where it induces apoptosis in various cancer cell types, reduces inflammation in cigarette smoke-damaged skin cells, and blocks angiogenesis and tumor growth—and disease modeling, including promotion of neurite growth in rat cortical neurons and protection against excitotoxic and neurotoxic injury.