GW2580, 25 mg

Supplied by STEMCELL Technologies as a 25 mg vial, this selective small-molecule inhibitor targets the colony-stimulating factor 1 receptor (CSF1R, also known as c-Fms tyrosine kinase) and is widely used across cell culture and in vivo research programs investigating macrophage biology, monocyte differentiation, osteoclastogenesis, and microglial activation.

Working concentrations typically span 0.1 to 10 µM in cell-based assays, with the compound first dissolved in DMSO as a concentrated stock before dilution into aqueous media. Researchers apply GW2580 to suppress macrophage proliferation and survival, dissect CSF1-dependent signaling cascades, and evaluate the contribution of tumor-associated macrophages in cancer research. Published applications include immunology, neuroscience, and bone biology workflows, including studies of rheumatoid arthritis, neuroinflammation, and bone remodeling.

For handling, the vial should be stored at -20 degrees C, protected from light and moisture, with aliquoting recommended to limit repeated freeze-thaw exposure. Each 25 mg unit provides ample material for hundreds of experiments depending on assay scale, and the inhibitor is compatible with standard multi-well plate formats as well as flow cytometry, western blot, and immunohistochemistry readouts. The product is labeled for research use only and is intended for laboratory investigation by trained personnel.