GSK621, 1 mg

GSK621 is a selective small-molecule agonist of AMP-activated protein kinase (AMPK) that activates both the α1 and α2 catalytic subunit complexes. Supplied as 1 mg of lyophilized powder from STEMCELL Technologies, this compound is widely used in cell biology and oncology research to probe AMPK-dependent signaling pathways, including autophagy induction, metabolic regulation, and apoptosis in acute myeloid leukemia (AML) cell models. Researchers typically dissolve the compound in DMSO for in vitro assays, with working concentrations in the low micromolar range. The activator has been cited in published studies investigating metabolic stress, mitochondrial function, and the cytotoxic effects of AMPK activation in leukemic and solid tumor cell lines. The product ships as a single vial intended for research use only. Store the powder at -20°C, protected from light, and avoid repeated freeze-thaw cycles by preparing small aliquots in DMSO before use.